Table of Contents
SECTION I
GENERAL PRINCIPLES
Introduction
1. Pharmacokinetics: The dynamics of drug absorption, distribution, and elimination
2. Pharmacodynamics: Mechanisms ofdrug action and the relationship between drug concentration and effect
3. Principles of therapeutics
4. Principles of toxicology adn treatment of poisoning
5. Gene-based therapy
SECTION II
DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES
6. Neurotransmisson: The autonomic and somatic motor nervous systems
7. Muscarinic receptor agonists and antagonists
8. Anticholinesterase agents
9. Agents acting at the neuromuscular junction and autonomic ganglia
10. Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists 11. 5-Hydroxytryptamine (serotonin) receptor agonists and antagonists
SECTION III
DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM
12. Neurotransmission and the central nervous system
13. History and principles of anesthesiology
14. General anesthetics
15. Local anesthetics
16. Therapeutic gases
17. Hypnotics and sedatives; ethanol
18. Drugs and the treatment of psychiatric disorders: Psychosis and anxiety
19. Drugs and the treatment of psychiatric disorders: Depression and mania
20. Drugs effective in the therapy of the epilepsies
21. Drugs effective in the therapy of migraine
22. Treatment of central nervous system degenerative disorders
23. Opioid analgesics and antagonists
24. Drug addiction and drug abuse
SECTION IV
AUTACOIDS; DRUG THERAPY OF INFLAMMATION
Introduction
25. Histamine, bradykinin and their antagonists
26. Lipid-derived autacoids: Eicosanoids and platelet-activating factor
27. Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout
28. Drugs used in the treatment of asthma
SECTION V
DRUGS AFFECTING RENAL AND CARDIOVASCULAR FUNCTION
29. Diuretics
30. Vasopressin and other agents affecting the renal conservation of water
31. Renin and angiotensin
32. Drugs used for the treatment of myocardial ischemia
33. Antihypertensive agents and the drug therapy of hypertension
34. Pharmacological treatment of heart failure
35. Antiarrhythmic drugs
36. Drugs used in the treatment of hyperlipoproteinemias
SECTION VI
DRUGS AFFECTING GASTROINTESTINAL FUNCTION
37. Agents for control of gastric acidity and treatment of peptic ulcers
38. Agents affecting gastrointestinal water flux and motility; Emesis and antiemetics; Bile acids and pancreatic enzymes
SECTION VII
DRUGS AFFECTING UTERINE MOTILITY
39. Agents that cause contraction or relaxation of the uterus
SECTION VIII
CHEMOTHERAPY OF PARASITIC INFECTIONS
40. Drugs used in the chemotherapy of protozoal infectoins: Malaria
41. Drugs used in the chemotherapy of protozoal infections: Trypanosomiasis, leishmaniasis, amebiasis, giardiasis, trichomoniasis, and other protozoal infections
42. Drugs used in the chemotherapy of helminthiasis
SECTION IX
CHEMOTHERAPY OF MICROBIAL DISEASES
43. Antimicrobial agents: General considerations
44. Antimicrobial agents: Sulfonamides, trimethoprim-sulfamethoxazole, quinolones, and agents for urinary tract infections
45. Antimicrobial agents: Penicillins, cephalosporins, and other beta-lactam antibiotics
46. Antimicrobial agents: The aminoglycosides
47. Antimicrobial agents: Tetracyclines, chloramphenicol. erythromycin, and miscellaneous antibacterial agents
48. Antimicrobial agents: Drugs used in the cehmotherapy of tuberculosis and leprosy
49. Antimicrobial agents: Antifungal agents
50. Antimicrobial agents: Antiviral agents
SECTION X
CHEMOTHERAPY OF NEOPLASTIC DISEASES
Introduction
51. Antineoplastic agents
SECTION XI
DRUGS USED FOR IMMUNOMODULATION
Introduction
52. Immunomodulators: Immunosuppressive agents and immunostimulants
SECTION XII
DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS
53. Hematopoietic agents: Growth factors, minerals, and vitamins
54. Anticoagulant, thrombolytic, and antiplatelet drugs
SECTION XIII
HORMONES AND HORMONE ANTAGONISTS
55. Adenohypophyseal hormones and their hypothalamic releasing factors
56. Thyroid and antithyroid drugs
57. Estrogens and progestins
58. Androgens
59. Adrenocorticotropic hormone: Adrenocortical steroids and their synthetic analogs; Inhibitors of the synthesis and actions of adrenocortical hormones
60. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas
61. Agents affecting calcification and bone turnover: Calcium, phosphate, parathyroid hormone, vitamine D, calcitonin, and other compounds
SECTION XIV
THE VITAMINS
Introduction
62. Water-soluble vitamins: The vitamin B complex and ascorbic acid
63. Fat-soluble vitamins: Vitamins A, K, and E
SECTION XV
DERMATOLOGY
64. Dermatological pharamcology
SECTION XVI
OPHTHALMOLOGY
65. Ocular pharmacology
SECTION XVII
TOXICOLOGY
66. Heavy metals and heavy-metal antagonists
67. Nonmetallic environmental toxicants: Air pollutants, solvents, vapors, and pesticides
APPENDICES
I. Principles of prescription order writing and patient compliance instructions
II. Design and optimization of dosage regimens; Pharmacokinetic data